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Membrane Target Systems are quality assured frozen membranes from cells that express recombinant or endogenous receptors. We submit every batch of receptor to stringent quality control testing that includes saturation radioligａnd binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPgS data is also provided for some of our Gi coupled receptors.

Membranes are carefully prepared and ready for a variety of HTS applications, including radioligａnd binding (using either proximity methods, such as FlashPlate, or classical filtration methods). Products are packaged as frozen crude membrane preparations. One assay unit is defined as micrograms of protein, defined by competition binding assay (filtration). A complete product description and recommended protocol are included on the Certificate of Analysis.

Some of our receptors may be restricted for sale in specified countries. Please inquire.